After his ship goes down, Edward Parker is rescued at sea. Parker gets into a fight with Captain Davies of the Apia and the Captain tosses him overboard while making a delivery to the tiny tropical island of Dr. Moreau. Parker discovers that Moreau has good reason to be so secretive on his lonely island. The doctor is a whip-cracking task master to a growing population of his own gruesome human/animal experiments. He does have one prize result, Lota the beautiful panther woman. Parker's fortunes for escape look up after his fiancée Ruth finds him with the help of fearless Captain Donohue. However, when Moreau's tribe of near-humans rises up to rebel, no one is safe...

It's a hundred years later, and the dhampir Rayne has arrived in the town of Deliverance, Montana where a group of vampire cowboys have emerged. Led by Billy the Kid, hell-bent on creating his own kingdom, he slaughters townspeople and rounds up children. He spares the life of Chicago Chronicle reporter Newton Pyles. Rayne aligns herself with Pat Garret, a member of the long-thought-dead Brimstone society, a dishonest preacher, and a lowlife named Franson, to stop Billy the Kid and show the world how the West was really won.